AvailOm®
Free fatty acid DHA complexed with L-lysine for direct absorption — clinically shown to deliver up to 8x greater EPA+DHA bioavailability than standard ethyl ester fish oil, powering overnight inflammation resolution and synaptic membrane repair.
Primacy Research
AvailOm® Supports
Brain DHA Delivery and Cognitive Function
Delivers DHA as a free fatty acid lysine complex with up to 8x greater bioavailability than standard ethyl ester fish oil (Schön et al., 2024). A large clinical trial (n=485) showed DHA reversed age-related memory decline equivalent to 3 years of cognitive aging.
A Healthy Inflammatory Response During Sleep
Your brain converts DHA into specialized molecules that help support the body's natural inflammation resolution process overnight. This is the biological pathway for managing the inflammatory load your body accumulates during the day.
Synaptic Membrane Maintenance Overnight
DHA is the most abundant omega-3 in your brain and helps maintain flexible, responsive synaptic membranes. AvailOm® provides the building material your brain needs to support and maintain these connections during sleep.
Your Brain’s Resolution System Is Offline
DHA is the most abundant omega-3 fatty acid in your brain — comprising 15–20% of gray matter fatty acids by weight. Yet 68–95% of Western adults have suboptimal omega-3 status. Without adequate DHA, your brain cannot produce the specialized pro-resolving mediators that actively clear inflammation, and synaptic membranes progressively stiffen with every passing year.
Failed Resolution
Chronic neuroinflammation persists not because your immune system is overactive, but because the resolution phase never completes. Without DHA-derived resolvins, protectins, and maresins, inflammatory signals fire indefinitely — damaging the synaptic structures they were meant to protect.
Membrane Starvation
Brain synaptic membranes progressively lose DHA with age, replaced by inferior fatty acids like DPA n-6 that slow receptor signaling, impair vesicle fusion, and reduce the signal-to-noise ratio across every synapse in your neural architecture.
The Absorption Bottleneck
Standard omega-3 supplements deliver DHA as ethyl ester or triglyceride — forms that require emulsification by bile salts and hydrolysis by pancreatic lipases before absorption can occur. This multi-step process is slow, incomplete, and highly variable between individuals. Much of the DHA you swallow never makes it into circulation.
How AvailOm® Works
AvailOm® delivers DHA as a free fatty acid complexed with the amino acid L-lysine — a patented algae-derived powder form developed by Evonik. Unlike triglyceride or ethyl ester omega-3s, the FFA-lysine complex dissociates in stomach acid and is absorbed directly, bypassing the enzymatic bottlenecks that limit conventional fish oil.
Lysine Salt Dissociation in Stomach Acid
AvailOm® delivers DHA as a free fatty acid (FFA) complexed with L-lysine. In the acidic environment of the stomach, this lysine salt rapidly dissociates, releasing free fatty acid DHA. Unlike ethyl ester or triglyceride forms, there is no ester bond to cleave — the DHA is already in its absorbable free acid form before it even reaches the intestine.
Direct Absorption — No Bile Salts or Lipase Required
Standard omega-3 supplements require bile salt emulsification and pancreatic lipase hydrolysis before absorption can begin — a rate-limiting process that varies widely between individuals and is impaired by low-fat meals, digestive insufficiency, and aging. Free fatty acid DHA bypasses both steps entirely, moving directly across the intestinal epithelium without enzymatic processing.
Rapid Chylomicron Incorporation & Plasma Delivery
Once absorbed, free fatty acid DHA is rapidly re-esterified in enterocytes and incorporated into chylomicrons for systemic delivery via the lymphatic system. Schön et al. (2024) demonstrated in a three-way crossover RCT (n=21) that the AvailOm FFA-lysine formulation achieved 8.09x higher EPA+DHA bioavailability compared to ethyl ester and 1.44x compared to triglyceride form — confirming dramatically faster and more complete plasma delivery.
Membrane Fluidity & Receptor Optimization
DHA’s 22-carbon chain with 6 double bonds (22:6n-3) creates extreme conformational flexibility in synaptic membranes. This increases lateral diffusion of signaling proteins, enhances receptor conformational changes, improves synaptic vesicle fusion kinetics, and modulates lipid raft organization — which is thought to make signaling faster and more efficient.
SPM Production — The Resolution Cascade
Membrane DHA is enzymatically converted into specialized pro-resolving mediators: Resolvin D1/D2 (block neutrophil infiltration, promote debris clearance), Neuroprotectin D1 (protects neurons from oxidative apoptosis, upregulates anti-apoptotic Bcl-2), and Maresins (promote tissue regeneration). This is active resolution — not suppression, but a biological “off switch” for inflammation.
What the Research Shows
DHA’s cognitive and neuroprotective effects are among the most extensively studied in nutritional neuroscience. Large-scale RCTs and prospective cohorts establish the cognitive benefits of DHA, while AvailOm-specific crossover trials demonstrate the bioavailability advantage of the FFA-lysine delivery form.
Yurko-Mauro K et al. (2010). Alzheimer’s & Dementia, 6(6):456–464. Healthy older adults (mean age ~70) with mild memory complaints, 900 mg/day algal DHA, 24 weeks. p=0.03.
Stonehouse W et al. (2013). American Journal of Clinical Nutrition, 97(5):1134–1143. Healthy adults aged 18–45, 1,160 mg DHA/day, 6 months. Episodic memory improvement in women; reaction time improvement in both sexes.
Douaud G et al. (2013). Proceedings of the National Academy of Sciences, 110(23):9523–9528. Elderly subjects with MCI; B-vitamin neuroprotection was almost entirely confined to participants with high baseline omega-3 levels. Omega-3 status is the gatekeeper for B-vitamin efficacy.
Tan ZS et al. (2012). Neurology, 78(9):658–664. Framingham Offspring Cohort. Lowest DHA quartile showed smaller total brain volumes, greater white matter hyperintensities, and lower scores on visual memory, executive function, and abstract thinking.
Your Nightly Dose in RESET
Why this dose works: The MIDAS trial demonstrated cognitive benefits at 900 mg/day DHA in standard triglyceride form. RESET delivers ~500 mg DHA as a free fatty acid lysine complex, which is absorbed directly without requiring bile salt emulsification or pancreatic lipase hydrolysis. Schön et al. (2024) demonstrated 8.09x greater EPA+DHA bioavailability vs. ethyl ester and 1.44x vs. triglyceride in a three-way crossover RCT. This means effective systemic delivery may approach that of higher conventional doses, though cognitive equivalence at lower doses has not been established in clinical trials. Plant-based algal sourcing eliminates ocean-borne contaminant concerns (heavy metals, PCBs) and is suitable for vegetarian protocols.
The Kennedy Pathway Triad — APEX + RESET Combined Protocol
The Kennedy pathway is the primary biosynthetic route for phosphatidylcholine — the most abundant phospholipid in synaptic membranes. APEX provides choline + CTP during peak daytime demand; RESET provides DHA during overnight membrane remodeling. Wurtman et al. (MIT) showed the combination of all three substrates produces synergistic increases in synaptic membrane synthesis and dendritic spine density.
How AvailOm® Connects Across the System
AvailOm® is the structural linchpin of the Primacy protocol — connecting overnight inflammation resolution, membrane repair, and the circadian Kennedy Pathway Triad that spans both APEX and RESET.
The Kennedy Pathway Triad
APEX provides Citicoline (choline + cytidine) and Uridine (UTP → CTP) during the day to upregulate phosphatidylcholine synthesis enzymes. RESET provides AvailOm® DHA at night — the preferred sn-2 fatty acid for newly synthesized PC. Wurtman et al. (MIT) demonstrated that combining all three substrates produces synergistic increases in synaptic membrane synthesis, dendritic spine density, and neurite outgrowth that far exceed any single substrate alone. The circadian distribution is designed so substrate availability tracks the brain’s natural demand cycle.
The B-Vitamin Gatekeeper Effect
Douaud et al. (2013, PNAS) showed that APEX’s B-vitamin complex (B6/P5P, B12, Folate) only protects brain gray matter when omega-3 status is adequate — reducing atrophy by up to 73% in AD-vulnerable regions. Without sufficient DHA, B vitamins provide virtually no structural brain protection despite lowering homocysteine. RESET’s AvailOm® DHA is designed to help meet the omega-3 threshold, positioned to support the neuroprotective potential of APEX’s methylation stack.
Complete Inflammation Management
CherryPURE® inhibits COX-1/COX-2 to block new inflammatory cascades (initiation suppression). AvailOm® DHA provides the substrate for resolvins, protectins, and maresins that actively clear existing inflammation (resolution). Levagen® PEA acts through the endocannabinoid system via PPAR-alpha and indirect CB2 modulation — a third, non-overlapping anti-inflammatory pathway. Together, they are designed to form a three-phase overnight inflammation management system: suppress, resolve, and support recovery.
PS-DHA Assembly Complex
The predominant phosphatidylserine species in the brain is PS-DHA (PS with DHA at sn-2). Actiserine® provides the PS scaffold, L-Serine provides the amino acid headgroup, and AvailOm® DHA provides the preferred fatty acid tail. S-Acetyl Glutathione + Pycnogenol® form a layered antioxidant shield protecting DHA’s six double bonds from peroxidation — preserving membrane integrity during overnight repair.
Key Takeaways
Free Fatty Acid DHA — Direct Absorption, No Bottleneck
AvailOm® delivers DHA as a free fatty acid lysine complex that dissociates in stomach acid, releasing DHA in its directly absorbable form. Unlike ethyl ester or triglyceride fish oil, it requires no bile salt emulsification or pancreatic lipase hydrolysis. Schön et al. (2024) demonstrated up to 8x greater EPA+DHA bioavailability versus ethyl ester in a crossover RCT.
Active Resolution, Not Just Suppression
DHA is the precursor to resolvins, protectins, and maresins — specialized pro-resolving mediators that actively clear inflammation rather than merely blocking it. This is the biological “off switch” that 68–95% of adults lack due to omega-3 deficiency.
The Third Substrate in the Kennedy Pathway Triad
APEX provides Citicoline and Uridine during the day. RESET provides AvailOm® DHA at night. Together, they deliver all three substrates for phosphatidylcholine synthesis — the primary membrane phospholipid in synapses — distributed across the circadian cycle to match the brain’s natural demand.
The Omega-3 Gatekeeper for B-Vitamin Neuroprotection
Douaud et al. (2013) demonstrated that B vitamins protect brain gray matter only when omega-3 status is adequate — up to 73% atrophy reduction with high omega-3, versus virtually zero without it. AvailOm® in RESET is positioned to support the neuroprotective potential of every B vitamin in APEX. Each product’s efficacy may be conditional on the other.
Frequently Asked Questions
What is AvailOm®?
AvailOm® is a high-DHA algal omega-3 ingredient developed by Evonik that delivers DHA as a free fatty acid (FFA) complexed with the amino acid L-lysine. This FFA-lysine form dissociates in stomach acid, releasing DHA in its directly absorbable free acid form — bypassing the bile salt emulsification and pancreatic lipase hydrolysis that standard triglyceride or ethyl ester fish oil requires.
How is AvailOm® different from regular fish oil?
Standard fish oil delivers DHA as ethyl ester or triglyceride, which must be emulsified by bile salts and hydrolyzed by pancreatic lipases before absorption — a slow, incomplete, and variable process. AvailOm® delivers DHA as a free fatty acid lysine salt that dissociates in the stomach, allowing direct absorption. A 2024 crossover RCT (Schön et al.) showed 8.09x greater EPA+DHA bioavailability vs. ethyl ester and 1.44x vs. triglyceride form.
How much DHA does RESET provide?
RESET delivers 1,000 mg of AvailOm® 50 High DHA Algae per serving, standardized to approximately 50% DHA content, yielding approximately 500 mg of DHA as a free fatty acid lysine complex. Based on crossover bioavailability data, effective systemic delivery may approach that of higher conventional doses, though cognitive equivalence at lower doses has not been established in clinical trials.
Why is DHA important for the brain?
DHA comprises 15–20% of gray matter fatty acids and is essential for synaptic membrane fluidity, receptor signaling, and the production of specialized pro-resolving mediators that clear neuroinflammation. Low DHA status (affecting 68–95% of Western adults) is associated with smaller brain volumes, greater white matter damage, and accelerated cognitive aging.
What is the Kennedy Pathway connection?
The Kennedy pathway is the primary biosynthetic route for phosphatidylcholine — the most abundant phospholipid in synaptic membranes. APEX provides choline (Citicoline) and UTP (Uridine) during the day; RESET provides DHA (AvailOm®) at night as the sn-2 fatty acid. This circadian triad delivers all three substrates for synergistic membrane synthesis.
Is AvailOm® suitable for vegetarians?
Yes. AvailOm® is derived from algae (Schizochytrium sp.), not fish. It provides highly bioavailable DHA without ocean-sourced contaminant concerns (heavy metals, PCBs, dioxins) and is suitable for vegetarian and vegan protocols.
References
- [1]Schön, C., Lammer, F., Spengler, E., & Rist, M. J. (2024). Superior bioavailability of EPA and DHA from a L-lysine salt formulation: a randomized, three-way crossover study. Food & Nutrition Research, 68, 11028.View
- [2]Hussey, E. K., Portelli, S., Bhatt, D., Fayyaz, S., Amin, N., & Park, J. S. (2020). In vitro dissolution behaviour and absorption in humans of a novel mixed l-lysine salt formulation of EPA and DHA. Prostaglandins, Leukotrienes and Essential Fatty Acids, 163, 102206.View
- [3]Yurko-Mauro, K., McCarthy, D., Rom, D., Nelson, E. B., Ryan, A. S., Blackwell, A., Salem, N., & Stedman, M. (2010). Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimer’s & Dementia, 6(6), 456–464.View
- [4]Stonehouse, W., Conlon, C. A., Podd, J., Hill, S. R., Minihane, A. M., Haskell, C., & Kennedy, D. (2013). DHA supplementation improved both memory and reaction time in healthy young adults: A randomized controlled trial. The American Journal of Clinical Nutrition, 97(5), 1134–1143.View
- [5]Douaud, G., Refsum, H., de Jager, C. A., Jacoby, R., Nichols, T. E., Smith, S. M., & Smith, A. D. (2013). Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment. Proceedings of the National Academy of Sciences, 110(23), 9523–9528.View
- [6]Tan, Z. S., Harris, W. S., Beiser, A. S., Au, R., Himali, J. J., Debette, S., Pikula, A., DeCarli, C., Wolf, P. A., Vasan, R. S., Robins, S. J., & Seshadri, S. (2012). Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging. Neurology, 78(9), 658–664.View
Resolve. Repair. Rebuild.
AvailOm® is one of 25 active ingredients in RESET, engineered to work as a system — resolving daytime inflammation, repairing synaptic membranes, and providing the structural DHA that makes every other ingredient in the protocol more effective.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.